The Benefits of Spinal Manipulation in 2025: Why HVLA Still Matters
Chiropractic care has continued to evolve, but one technique remains a staple in spinal health: High-Velocity, Low-Amplitude (HVLA) spinal manipulation. While various low-force techniques—such as flexion distraction, drop tables, and instrument-assisted methods—offer valuable benefits, today’s focus is on the classic hands-on approach that delivers that satisfying "pop" during treatment.
HVLA manipulation is a well-researched and widely used technique in chiropractic and manual therapy. Defined by a rapid, controlled thrust that moves a joint just beyond its normal physiological range (without exceeding anatomical integrity), HVLA provides a host of therapeutic benefits. But what exactly makes this technique so effective?
In this blog, we’ll explore five key benefits of HVLA spinal manipulation, backed by research, to help you better understand why this time-tested approach continues to be a cornerstone of chiropractic care. Whether you're a clinician looking to refine your technique or a patient curious about what’s happening when you hear that audible release, this deep dive will provide clarity on the powerful impact of spinal manipulation.
1. Biomechanical Effects
HVLA adjustments affect the spinal joints, muscles, and ligaments, leading to:
Restoration of joint mobility: HVLA techniques help to reduce joint restriction by stretching and repositioning spinal facet joints. (2)
Reduction of spinal fixation: The thrust can break adhesions in the joint capsule and surrounding connective tissue, restoring normal motion.
Decreased intra-articular pressure: It reduces joint stiffness and improves lubrication through synovial fluid motion. (3)
Cavitation phenomenon: The “popping” sound heard during adjustments is attributed to the release of gas bubbles (CO₂, N₂, O₂) from the synovial fluid due to sudden pressure changes.
If you want a deeper understanding of joint manipulation, check out this blog that breaks down the science behind the "pop," comparing historical and modern models to refine how you educate patients and approach treatment.
2. Neurological Effects
HVLA spinal manipulation modulates the central and peripheral nervous system by:
Pain Modulation via the Gate Control Theory: The rapid mechanical stimulus activates mechanoreceptors in the spinal joints and soft tissues, reducing the transmission of pain signals from nociceptors to the brain.
Reflexive Muscle Relaxation: Adjustments stimulate muscle spindle afferents and Golgi tendon organs, decreasing muscle hypertonicity and spasm relief.
Spinal Cord Modulation: HVLA affects the dorsal horn of the spinal cord, altering sensory processing and reducing pain sensitivity.
Proprioceptive Recalibration: By restoring normal joint motion, HVLA improves proprioceptive feedback, reducing motor control dysfunction.
If you want more insights on chronic pain, you won't want to miss this! Check out this past blog featuring an interview with Anthony Nicholson from CDI, highlighting the crucial role of assessment and treatment in managing chronic pain.
3. Neurochemical & Inflammatory Modulation
Endorphin and Enkephalin Release: HVLA manipulation stimulates the release of endogenous opioids, contributing to pain relief and relaxation.
Reduction in Pro-Inflammatory Cytokines: Studies indicate that spinal manipulation can reduce levels of TNF-α, IL-6, and PGE2, which are key mediators of inflammation in conditions like chronic low back pain.
Activation of the Hypothalamic-Pituitary-Adrenal (HPA) Axis: HVLA triggers cortisol release, which has anti-inflammatory and stress-modulating effects.
4. Vascular & Cerebrospinal Fluid (CSF) Effects
Increased Blood Flow & Oxygenation: Manipulation enhances microcirculation in spinal muscles and soft tissues, promoting tissue healing.
Enhanced Cerebrospinal Fluid Circulation: Some studies suggest that spinal adjustments improve CSF dynamics, which may benefit conditions like cervicogenic headaches.
5. Psychosocial Effects
Placebo & Expectation Effects: A patient’s belief in the effectiveness of manipulation can enhance pain relief through psychological and neurobiological mechanisms.
Reduction in Fear-Avoidance Behavior: Pain relief from HVLA adjustments can encourage patients to move more freely, preventing chronic pain syndromes.
The psychological aspect of being a chiropractor is sometimes just as important as the physical aspect of treatment. Here’s an easy-to-follow blog with actionable strategies to help you better support your patients in your office today.
| Mechanism | Physiological Effect | Clinical Benefit |
|---|---|---|
| Biomechanical | Joint mobility restoration, adhesion release, intra-articular pressure reduction | Improved spinal function, pain relief |
| Neurological | Pain gating, proprioceptive feedback improvement, reflexive muscle relaxation | Reduced muscle tension, decreased pain perception |
| Neurochemical | Endorphin release, cytokine modulation, cortisol secretion | Anti-inflammatory effects, stress reduction |
| Vascular & CSF | Increased blood flow, CSF circulation improvement | Tissue healing, reduced headaches |
| Psychosocial | Placebo response, reduction in fear-avoidance behavior | Increased patient confidence in movement |
Conclusion
When it comes to non-surgical, and non-pharmacological care for the treatment of musculoskeletal complaints, my money is on spinal manipulation. HVLA spinal manipulation achieves therapeutic benefits through a multifactorial mechanism involving biomechanical, neurological, neurochemical, and vascular effects. The combination of joint mobilization, pain inhibition, muscle relaxation, and neuroimmune modulation makes it a highly effective intervention for conditions like low back pain, neck pain, sciatica, and headaches.
The best chiropractors never stop learning. The best practices never stop evolving. And the best profession thrives when we support and challenge one another.
Join the 3,000+ DCs who are leading the charge toward a future where chiropractic care is recognized as the undeniable best choice for patients and payors alike.
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1. Alanazi, M. S., Degenhardt, B., Kelley-Franklin, G., Cox, J. M., Lipke, L., & Reed, W. R. (2025). Neuromuscular Response to High-Velocity, Low-Amplitude Spinal Manipulation—An Overview. Medicina, 61(2), 187.
2. César Fernández-de-las-Peñas, Cristina Alonso-Blanco, Joshua A. Cleland, Cleofás Rodríguez-Blanco, Francisco Alburquerque-Sendín, Changes in Pressure Pain Thresholds Over C5-C6 Zygapophyseal Joint After a Cervicothoracic Junction Manipulation in Healthy Subjects, Journal of Manipulative and Physiological Therapeutics, Volume 31, Issue 5, 2008, Pages 332-337
3. Chinonso Vincent Nweke (2023). Joint Mobilization and Its Resultant Effects. Cross Current Int J Med Biosci, 5(3), 72-77.
